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Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.

Cyclosporin A (CsA) is a potent immunosuppressive agent, now gaining wide application in human organ transplantation. The immunosuppressive activity of CsA is at least in part due to inhibition of lymphokine production by activated T lymphocytes. Specifically, inhibition of T-cell growth factor (TCG...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Krönke, M, Leonard, W J, Depper, J M, Arya, S K, Wong-Staal, F, Gallo, R C, Waldmann, T A, Greene, W C
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1984
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391668/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6332315/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.16.5214
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