Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal

The altered metabolism in most tumor cells consists of elevated glucose uptake and increased glycolysis even in the presence of high oxygen tension. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an obligatory enzyme in glycolysis. Here, we report that acetylation at lysine 254 (K254) increases...

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Main Authors: Li, Tingting, Liu, Mengxi, Feng, Xu, Wang, Zhen, Das, Indrani, Xu, Yanping, Zhou, Xin, Sun, Yiping, Guan, Kun-Liang, Xiong, Yue, Lei, Qun-Ying
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916574/
https://ncbi.nlm.nih.gov/pubmed/24362262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.531640
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