Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal

The altered metabolism in most tumor cells consists of elevated glucose uptake and increased glycolysis even in the presence of high oxygen tension. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an obligatory enzyme in glycolysis. Here, we report that acetylation at lysine 254 (K254) increases...

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Main Authors: Li, Tingting, Liu, Mengxi, Feng, Xu, Wang, Zhen, Das, Indrani, Xu, Yanping, Zhou, Xin, Sun, Yiping, Guan, Kun-Liang, Xiong, Yue, Lei, Qun-Ying
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Metabolism
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916574/
https://ncbi.nlm.nih.gov/pubmed/24362262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.531640
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