Inducible Deletion of CD28 Prior to Secondary Nippostrongylus brasiliensis Infection Impairs Worm Expulsion and Recall of Protective Memory CD4(+) T Cell Responses

IL-13 driven Th2 immunity is indispensable for host protection against infection with the gastrointestinal nematode Nippostronglus brasiliensis. Disruption of CD28 mediated costimulation impairs development of adequate Th2 immunity, showing an importance for CD28 during the initiation of an immune r...

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Detalhes bibliográficos
Main Authors: Ndlovu, Hlumani, Darby, Mathew, Froelich, Monika, Horsnell, William, Lühder, Fred, Hünig, Thomas, Brombacher, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916406/
https://ncbi.nlm.nih.gov/pubmed/24516382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003906
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