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A phase II clinical trial of polyethylene glycol-conjugated L-asparaginase in patients with advanced ovarian cancer: Early closure for safety

The anti-angiogenic activity of L-asparaginase (L-ASP) and the sensitivity of ovarian cancer cell lines to L-ASP has been previously demonstrated by preclinical findings. The aim of this clinical trial was to translate those findings and evaluate the activity of polyethylene glycol-conjugated L-aspa...

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Detalhes bibliográficos
Main Authors: HAYS, JOHN L., KIM, GEOFF, WALKER, AMANDA, ANNUNZIATA, CHRISTINA M., LEE, JUNG-MIN, SQUIRES, JENNIFER, HOUSTON, NICOLE, STEINBERG, SETH M., KOHN, ELISE C.
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916154/
https://ncbi.nlm.nih.gov/pubmed/24649212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mco.2013.99
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