TNF-α Gene Silencing Using Polymerized siRNA/Thiolated Glycol Chitosan Nanoparticles for Rheumatoid Arthritis

Among various proinflammatory cytokines involved in the pathogenesis of rheumatoid arthritis (RA), tumor necrosis factor (TNF)-α plays a pivotal role in the release of other cytokines and induction of chronic inflammation. Even though siRNA has the therapeutic potential, they have a challenge to be...

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Detalhes bibliográficos
Main Authors: Lee, So Jin, Lee, Aeju, Hwang, Seung Rim, Park, Jong-Sung, Jang, Jiyeon, Huh, Myung Sook, Jo, Dong-Gyu, Yoon, Soo-Young, Byun, Youngro, Kim, Sun Hwa, Kwon, Ick Chan, Youn, Inchan, Kim, Kwangmeyung
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916041/
https://ncbi.nlm.nih.gov/pubmed/24145554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.245
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