Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone

Proper activation of protein phosphatase 2A (PP2A) catalytic subunit is central for the complex PP2A regulation and is crucial for broad aspects of cellular function. The crystal structure of PP2A bound to PP2A phosphatase activator (PTPA) and ATPγS reveals that PTPA makes broad contacts with the st...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Guo, Feng, Stanevich, Vitali, Wlodarchak, Nathan, Sengupta, Rituparna, Jiang, Li, Satyshur, Kenneth A, Xing, Yongna
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2014
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915903/
https://ncbi.nlm.nih.gov/pubmed/24100351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2013.138
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