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Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone

Proper activation of protein phosphatase 2A (PP2A) catalytic subunit is central for the complex PP2A regulation and is crucial for broad aspects of cellular function. The crystal structure of PP2A bound to PP2A phosphatase activator (PTPA) and ATPγS reveals that PTPA makes broad contacts with the st...

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Autors principals: Guo, Feng, Stanevich, Vitali, Wlodarchak, Nathan, Sengupta, Rituparna, Jiang, Li, Satyshur, Kenneth A, Xing, Yongna
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915903/
https://ncbi.nlm.nih.gov/pubmed/24100351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2013.138
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