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Interaction of hydrolysis-resistant analogs of cyclic GMP with the phosphodiesterase and light-sensitive channel of retinal rod outer segments.

cGMP opens cation-selective channels when applied to the cytoplasmic side of excised patches of membrane from retinal rod outer segments (ROS). If the light-sensitive channel in intact rods is gated only by cGMP, it should be possible to find a hydrolysis-resistant analog of cGMP that blocks the nor...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Zimmerman, A L, Yamanaka, G, Eckstein, F, Baylor, D A, Stryer, L
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1985
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391528/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2417228/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.24.8813
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