Influence of O-methylated metabolite penetrating the blood–brain barrier to estimation of dopamine synthesis capacity in human L-[β-(11)C]DOPA PET

O-methyl metabolite (L-[β-(11)C]OMD) of (11)C-labeled L-3,4-dihydroxyphenylalanine (L-[β-(11)C]DOPA) can penetrate into brain tissue through the blood–brain barrier, and can complicate the estimation of dopamine synthesis capacity by positron emission tomography (PET) study with L-[β-(11)C]DOPA. We...

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Autori principali: Matsubara, Keisuke, Ikoma, Yoko, Okada, Maki, Ibaraki, Masanobu, Suhara, Tetsuya, Kinoshita, Toshibumi, Ito, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915201/
https://ncbi.nlm.nih.gov/pubmed/24192636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2013.187
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