TMPRSS4 regulates levels of integrin α5 in NSCLC through miR-205 activity to promote metastasis

BACKGROUND: TMPRSS4 is a membrane-anchored protease involved in cell migration and invasion in different cancer types including lung cancer. TMPRSS4 expression is increased in NSCLC and its inhibition through shRNA reduces lung metastasis. However, molecular mechanisms leading to the protumorigenic...

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Detalles Bibliográficos
Main Authors: Larzabal, L, de Aberasturi, A L, Redrado, M, Rueda, P, Rodriguez, M J, Bodegas, M E, Montuenga, L M, Calvo, A
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2014
Assuntos:
Molecular Diagnostics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915125/
https://ncbi.nlm.nih.gov/pubmed/24434435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.761
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