Safety, tolerability, and biomarkers of the treatment of mice with aerosolized Toll-like receptor ligands

We have previously discovered a synergistically therapeutic combination of two Toll-like receptor ligands, an oligodeoxynucleotide (ODN) and Pam2CSK4. Aerosolization of these ligands stimulates innate immunity within the lungs to prevent pneumonia from bacterial and viral pathogens. Here we examined...

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Bibliographic Details
Main Authors: Alfaro, Victoria Y., Goldblatt, David L., Valverde, Gabriella R., Munsell, Mark F., Quinton, Lee J., Walker, Adam K., Dantzer, Robert, Varadhachary, Atul, Scott, Brenton L., Evans, Scott E., Tuvim, Michael J., Dickey, Burton F.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2014
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915096/
https://ncbi.nlm.nih.gov/pubmed/24567720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00008
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