CXCR4 antibody treatment suppresses metastatic spread to the lung of intratibial human osteosarcoma xenografts in mice

Current combined surgical and neo-adjuvant chemotherapy of primary metastatic osteosarcoma (OS) is ineffective, reflected by a 5-year survival rate of affected patients of less than 20 %. Studies in experimental OS metastasis models pointed to the CXCR4/CXCL12 homing axis as a novel target for OS me...

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Main Authors: Brennecke, Patrick, Arlt, Matthias J. E., Campanile, Carmen, Husmann, Knut, Gvozdenovic, Ana, Apuzzo, Tiziana, Thelen, Marcus, Born, Walter, Fuchs, Bruno
Format: Artigo
Sprog:Inglês
Udgivet: Springer Netherlands 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915086/
https://ncbi.nlm.nih.gov/pubmed/24390633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10585-013-9632-3
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