Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules

Aberrant AKT activation is prevalent across multiple human cancer lineages providing an important new target for therapy. Twenty-two independent phosphorylation sites have been identified on specific AKT isoforms likely contributing to differential isoform regulation. However, the mechanisms regulat...

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Hlavní autoři: Guo, Huifang, Gao, Meng, Lu, Yiling, Liang, Jiyong, Lorenzi, Philip L., Bai, Shanshan, Hawke, David H., Li, Jie, Dogruluk, Turgut, Scott, Kenneth L., Jonasch, Eric, Mills, Gordon B., Ding, Zhiyong
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915040/
https://ncbi.nlm.nih.gov/pubmed/23912456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.301
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