Steroid Resistance in COPD? Overlap and Differential Anti-Inflammatory Effects in Smokers and Ex-Smokers

BACKGROUND: Inhaled corticosteroids (ICS) reduce exacerbation rates and improve health status but can increase the risk of pneumonia in COPD. The GLUCOLD study, investigating patients with mild-to-moderate COPD, has shown that long-term (2.5-year) ICS therapy induces anti-inflammatory effects. The l...

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Detalhes bibliográficos
Main Authors: Hoonhorst, Susan J. M., ten Hacken, Nick H. T., Vonk, Judith M., Timens, Wim, Hiemstra, Pieter S., Lapperre, Thérèse S., Sterk, Peter J., Postma, Dirkje S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914834/
https://ncbi.nlm.nih.gov/pubmed/24505290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087443
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