Alterations of Pancreatic Islet Structure, Metabolism and Gene Expression in Diet-Induced Obese C57BL/6J Mice

The reduction of functional β cell mass is a key feature of type 2 diabetes. Here, we studied metabolic functions and islet gene expression profiles of C57BL/6J mice with naturally occurring nicotinamide nucleotide transhydrogenase (NNT) deletion mutation, a widely used model of diet-induced obesity...

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Main Authors: Roat, Regan, Rao, Vandana, Doliba, Nicolai M., Matschinsky, Franz M., Tobias, John W., Garcia, Eden, Ahima, Rexford S., Imai, Yumi
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914796/
https://ncbi.nlm.nih.gov/pubmed/24505268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086815
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