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Synthesis of 3-(3-Aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines That Have Antibacterial Activity and Also Inhibit Inorganic Pyrophosphatase

Inorganic pyrophosphatases are potential targets for the development of novel antibacterial agents. A pyrophosphatase-coupled high-throughput screening assay intended to detect o-succinyl benzoic acid coenzyme A (OSB CoA) inhibitors led to the unexpected discovery of a new series of novel inorganic...

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Detalhes bibliográficos
Main Authors: Lv, Wei, Banerjee, Biplab, Molland, Katrina L., Seleem, Mohamed N., Ghafoor, Adil, Hamed, Maha I., Wan, Baojie, Franzblau, Scott G., Mesecar, Andrew D., Cushman, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914758/
https://ncbi.nlm.nih.gov/pubmed/24315189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.11.011
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