Combining chemotherapeutic agents and netrin-1 interference potentiates cancer cell death

The secreted factor netrin-1 is upregulated in a fraction of human cancers as a mechanism to block apoptosis induced by netrin-1 dependence receptors DCC and UNC5H. Targeted therapies aiming to trigger tumour cell death via netrin-1/receptors interaction interference are under preclinical evaluation...

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Bibliographische Detailangaben
Hauptverfasser: Paradisi, Andrea, Creveaux, Marion, Gibert, Benjamin, Devailly, Guillaume, Redoulez, Emeline, Neves, David, Cleyssac, Elsa, Treilleux, Isabelle, Klein, Christian, Niederfellner, Gerhard, Cassier, Philippe A, Bernet, Agnès, Mehlen, Patrick
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons 2013
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914534/
https://ncbi.nlm.nih.gov/pubmed/24293316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201302654
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