Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5

The involvement of nitric oxide (NO) and cyclic GMP (cGMP) in neurogenesis has been progressively unmasked over the last decade. Phosphodiesterase 5 (PDE5) specifically degrades cGMP and is highly abundant in the mammalian brain. Inhibition of cGMP hydrolysis by blocking PDE5 is a possible strategy...

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Detalhes bibliográficos
Main Authors: Santos, Ana I., Carreira, Bruno P., Nobre, Rui J., Carvalho, Caetana M., Araújo, Inês M.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914480/
https://ncbi.nlm.nih.gov/pubmed/24550991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/878397
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