Diethyl pyrocarbonate: a chemical probe for secondary structure in negatively supercoiled DNA.
Purine residues located within regions of DNA that have the potential to form left-handed Z-helical structures are modified preferentially by diethyl pyrocarbonate; this hyperreactivity is dependent on the degree of negative superhelicity of the circular DNA molecules. As negative superhelical densi...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1985
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391431/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3865212/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.23.8009 |
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