HMGA-targeted phosphorothioate DNA aptamers increase sensitivity to gemcitabine chemotherapy in human pancreatic cancer cell lines

Elevated high mobility group A (HMGA) protein expression in pancreatic cancer cells is correlated with resistance to the chemotherapy agent gemcitabine. Here, we demonstrate use of HMGA-targeted AT-rich phosphorothioate DNA (AT-sDNA) aptamers to suppress HMGA carcinogenic activity. Cell growth of hu...

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Huvudupphovsmän: Watanabe, Miki, Sheriff, Sulaiman, Lewis, Kenneth B., Tinch, Stuart L., Cho, Junho, Balasubramaniam, Ambikaipakan, Kennedy, Michael A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914216/
https://ncbi.nlm.nih.gov/pubmed/22036895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2011.10.005
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