Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells

Peptide ligand-induced dimerization of the extracellular region of the epidermal growth factor receptor (sEGFR) is central to the signal transduction of many cellular processes. A small molecule microarray screen has been developed to search for non-peptide compounds able to bind to sEGFR. We descri...

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Autori principali: Sakanyan, Vehary, Angelini, Marie, Le Béchec, Mickael, Lecocq, Michèle Françoise, Benaiteau, Florence, Rousseau, Bénédicte, Gyulkhandanyan, Aram, Gyulkhandanyan, Lusine, Logé, Cédric, Reiter, Eric, Roussakis, Christos, Fleury, Fabrice
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913914/
https://ncbi.nlm.nih.gov/pubmed/24496106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03977
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