Rapid Diminution in the Level and Activity of DNA-Dependent Protein Kinase in Cancer Cells by a Reactive Nitro-Benzoxadiazole Compound

The expression and activity of DNA-dependent protein kinase (DNA-PK) is related to DNA repair status in the response of cells to exogenous and endogenous factors. Recent studies indicate that Epidermal Growth Factor Receptor (EGFR) is involved in modulating DNA-PK. It has been shown that a compound...

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Main Authors: Viviane A. O. Silva, Florian Lafont, Houda Benhelli-Mokrani, Magali Le Breton, Philippe Hulin, Thomas Chabot, François Paris, Vehary Sakanyan, Fabrice Fleury
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2016-05-01
Colecção:International Journal of Molecular Sciences
Assuntos:
DNA-PKcs
DNA repair
hydrogen peroxide
SOD1
nitro-benzoxadiazole
chemiosensitization
protein targeting
prostate cancer
Acesso em linha:http://www.mdpi.com/1422-0067/17/5/703
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