Abnormal Intracellular Calcium Signaling and SNARE-Dependent Exocytosis Contributes to SOD1G93A Astrocyte-Mediated Toxicity in Amyotrophic Lateral Sclerosis

Motor neurons are progressively and predominantly degenerated in ALS, which is not only induced by multiple intrinsic pathways but also significantly influenced by the neighboring glial cells. In particular, astrocytes derived from the SOD1 mutant mouse model of ALS or from human familial or sporadi...

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Auteurs principaux: Kawamata, Hibiki, Ng, Seng Kah, Diaz, Natalia, Burstein, Suzanne, Morel, Lydie, Osgood, Alexandra, Sider, Brittany, Higashimori, Haruki, Haydon, Philip G., Manfredi, Giovanni, Yang, Yongjie
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2014
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913875/
https://ncbi.nlm.nih.gov/pubmed/24501372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2689-13.2014
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