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Loss of melanoregulin (MREG) enhances cathepsin-D secretion by the retinal pigment epithelium
Cathepsin-D (Cat-D) is a major proteolytic enzyme in phagocytic cells. In the retinal pigment epithelium (RPE), it is responsible for the daily degradation of photoreceptor outer segments (POSs) to maintain retinal homeostasis. Melanoregulin (MREG)-mediated loss of phagocytic capacity has been linke...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3912860/ https://ncbi.nlm.nih.gov/pubmed/23611523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S0952523813000096 |
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