A polymorphism in the protein kinase C gene PRKCB is associated with α(2)-adrenoceptor-mediated vasoconstriction

OBJECTIVES: α(2)-Adrenoceptors (α(2)-AR) mediate both constriction and dilatation of blood vessels. There is substantial inter-individual variability in dorsal hand vein (DHV) constriction responses to α(2)-AR agonist activation. Genetic factors appear to contribute significantly to this variation....

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Autors principals: Posti, Jussi P., Salo, Perttu, Ruohonen, Saku, Valve, Laura, Muszkat, Mordechai, Sofowora, Gbenga G., Kurnik, Daniel, Stein, C. Michael, Perola, Markus, Scheinin, Mika, Snapir, Amir
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912740/
https://ncbi.nlm.nih.gov/pubmed/23337848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32835d247f
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