Mutation of a conserved serine in TM4 of opioid receptors confers full agonistic properties to classical antagonists.

The involvement of a conserved serine (Ser196 at the mu-, Ser177 at the delta-, and Ser187 at the kappa-opioid receptor) in receptor activation is demonstrated by site-directed mutagenesis. It was initially observed during our functional screening of a mu/delta-opioid chimeric receptor, mu delta2, t...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Claude, P A, Wotta, D R, Zhang, X H, Prather, P L, McGinn, T M, Erickson, L J, Loh, H H, Law, P Y
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39126/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8650158/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.12.5715
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