Mutation of a conserved serine in TM4 of opioid receptors confers full agonistic properties to classical antagonists.
The involvement of a conserved serine (Ser196 at the mu-, Ser177 at the delta-, and Ser187 at the kappa-opioid receptor) in receptor activation is demonstrated by site-directed mutagenesis. It was initially observed during our functional screening of a mu/delta-opioid chimeric receptor, mu delta2, t...
Gespeichert in:
| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1996
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39126/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8650158/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.12.5715 |
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