Base Pair Opening in a Deoxynucleotide Duplex Containing a cis-syn Thymine Cyclobutane Dimer Lesion

The cis-syn thymine cyclobutane dimer is a DNA photoproduct implicated in skin cancer. We compared the stability of individual base pairs in thymine dimer-containing duplexes to undamaged parent 10-mer duplexes. UV melting thermodynamic measurements, CD spectroscopy, and 2D NOESY NMR spectroscopy co...

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Auteurs principaux: Wenke, Belinda B., Huiting, Leah N., Frankel, Elisa B., Lane, Benjamin F., Núñez, Megan E.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912563/
https://ncbi.nlm.nih.gov/pubmed/24328089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401312r
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