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Maintained Cocaine Self-Administration Is Determined by Quantal Responses: Implications for the Measurement of Antagonist Potency

The change in frequency of cocaine self-administration as a function of the unit dose is widely assumed to represent a graded pharmacodynamic response. Alternatively, a pharmacological theory states that during maintained self-administration, a quantal response occurs at a minimum maintained cocaine...

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Detalhes bibliográficos
Main Authors: Norman, Andrew B., Tabet, Michael R., Norman, Mantana K., Tsibulsky, Vladimir L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912544/
https://ncbi.nlm.nih.gov/pubmed/24307200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.210690
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