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The Affinity of D(2)-Like Dopamine Receptor Antagonists Determines the Time to Maximal Effect on Cocaine Self-Administration

Differences in the time to maximal effect (T(max)) of a series of dopamine receptor antagonists on the self-administration of cocaine are not consistent with their lipophilicity (octanol-water partition coefficients at pH 7.4) and expected rapid entry into the brain after intravenous injection. It w...

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Библиографические подробности
Главные авторы: Norman, Andrew B., Tabet, Michael R., Norman, Mantana K., Fey, Brittney K., Tsibulsky, Vladimir L., Millard, Ronald W.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141900/
https://ncbi.nlm.nih.gov/pubmed/21606176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.183244
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