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The Affinity of D(2)-Like Dopamine Receptor Antagonists Determines the Time to Maximal Effect on Cocaine Self-Administration
Differences in the time to maximal effect (T(max)) of a series of dopamine receptor antagonists on the self-administration of cocaine are not consistent with their lipophilicity (octanol-water partition coefficients at pH 7.4) and expected rapid entry into the brain after intravenous injection. It w...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3141900/ https://ncbi.nlm.nih.gov/pubmed/21606176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.183244 |
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