Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus

Chronic stress as well as chronic treatment with glucocorticoids (GCs) primes the neuroinflammatory response to a subsequent pro-inflammatory challenge. However, it remains unclear whether chronic GCs sensitize the response of key CNS immune substrates (i.e. microglia) to pro-inflammatory stimuli. I...

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Autores principales: Frank, Matthew G., Hershman, Sarah A., Weber, Michael D., Watkins, Linda R., Maier, Steven F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912460/
https://ncbi.nlm.nih.gov/pubmed/24485491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.psyneuen.2013.11.006
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