Second generation hybrid polar compounds are potent inducers of transformed cell differentiation.

Hybrid polar compounds, of which hexamethylenebisacetamide (HMBA) is the prototype, are potent inducers of differentiation of murine erythroleukemia (MEL) cells and a wide variety of other transformed cells. HMBA has been shown to induce differentiation of neoplastic cells in patients, but is not an...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Richon, V M, Webb, Y, Merger, R, Sheppard, T, Jursic, B, Ngo, L, Civoli, F, Breslow, R, Rifkind, R A, Marks, P A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39124/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8650156/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.12.5705
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