Bone Marrow-Specific Knock-In of a Non-Activatable Ikkα Kinase Mutant Influences Haematopoiesis but Not Atherosclerosis in Apoe-Deficient Mice

BACKGROUND: The Ikkα kinase, a subunit of the NF-κB-activating IKK complex, has emerged as an important regulator of inflammatory gene expression. However, the role of Ikkα-mediated phosphorylation in haematopoiesis and atherogenesis remains unexplored. In this study, we investigated the effect of a...

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Detalhes bibliográficos
Main Authors: Tilstam, Pathricia V., Gijbels, Marion J., Habbeddine, Mohamed, Cudejko, Céline, Asare, Yaw, Theelen, Wendy, Zhou, Baixue, Döring, Yvonne, Drechsler, Maik, Pawig, Lukas, Simsekyilmaz, Sakine, Koenen, Rory R., de Winther, Menno P. J., Lawrence, Toby, Bernhagen, Jürgen, Zernecke, Alma, Weber, Christian, Noels, Heidi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911989/
https://ncbi.nlm.nih.gov/pubmed/24498325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087452
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