Nitric Oxide-Dependent Activation of CaMKII Increases Diastolic Sarcoplasmic Reticulum Calcium Release in Cardiac Myocytes in Response to Adrenergic Stimulation

Spontaneous calcium waves in cardiac myocytes are caused by diastolic sarcoplasmic reticulum release (SR Ca(2+) leak) through ryanodine receptors. Beta-adrenergic (β-AR) tone is known to increase this leak through the activation of Ca-calmodulin-dependent protein kinase (CaMKII) and the subsequent p...

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Autori principali: Curran, Jerry, Tang, Lifei, Roof, Steve R., Velmurugan, Sathya, Millard, Ashley, Shonts, Stephen, Wang, Honglan, Santiago, Demetrio, Ahmad, Usama, Perryman, Matthew, Bers, Donald M., Mohler, Peter J., Ziolo, Mark T., Shannon, Thomas R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911966/
https://ncbi.nlm.nih.gov/pubmed/24498331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087495
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