Evolution of the Influenza A Virus Genome during Development of Oseltamivir Resistance In Vitro

Influenza A virus (IAV) is a major cause of morbidity and mortality throughout the world. Current antiviral therapies include oseltamivir, a neuraminidase inhibitor that prevents the release of nascent viral particles from infected cells. However, the IAV genome can evolve rapidly, and oseltamivir r...

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Detalhes bibliográficos
Main Authors: Renzette, Nicholas, Caffrey, Daniel R., Zeldovich, Konstantin B., Liu, Ping, Gallagher, Glen R., Aiello, Daniel, Porter, Alyssa J., Kurt-Jones, Evelyn A., Bolon, Daniel N., Poh, Yu-Ping, Jensen, Jeffrey D., Schiffer, Celia A., Kowalik, Timothy F., Finberg, Robert W., Wang, Jennifer P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911755/
https://ncbi.nlm.nih.gov/pubmed/24155392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01067-13
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