Mosquito Saliva Serine Protease Enhances Dissemination of Dengue Virus into the Mammalian Host

Dengue virus (DENV), a flavivirus of global importance, is transmitted to humans by mosquitoes. In this study, we developed in vitro and in vivo models of saliva-mediated enhancement of DENV infectivity. Serine protease activity in Aedes aegypti saliva augmented virus infectivity in vitro by proteol...

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Détails bibliographiques
Auteurs principaux: Conway, Michael J., Watson, Alan M., Colpitts, Tonya M., Dragovic, Srdjan M., Li, Zhiyong, Wang, Penghua, Feitosa, Fabiana, Shepherd, Denueve T., Ryman, Kate D., Klimstra, William B., Anderson, John F., Fikrig, Erol
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2014
Sujets:
Virus-Cell Interactions
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911723/
https://ncbi.nlm.nih.gov/pubmed/24131723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02235-13
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