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Impact of Potential Permissive Neuraminidase Mutations on Viral Fitness of the H275Y Oseltamivir-Resistant Influenza A(H1N1)pdm09 Virus In Vitro, in Mice and in Ferrets

Neuraminidase (NA) mutations conferring resistance to NA inhibitors (NAIs) generally compromise the fitness of influenza viruses. The only NAI-resistant virus that widely spread in the population, the A/Brisbane/59/2007 (H1N1) strain, contained permissive mutations that restored the detrimental effe...

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Main Authors: Abed, Yacine, Pizzorno, Andrés, Bouhy, Xavier, Rhéaume, Chantal, Boivin, Guy
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911590/
https://ncbi.nlm.nih.gov/pubmed/24257597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02681-13
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