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Vaccinia-Related Kinase 2 Mediates Accumulation of Polyglutamine Aggregates via Negative Regulation of the Chaperonin TRiC

Misfolding of proteins containing abnormal expansions of polyglutamine (polyQ) repeats is associated with cytotoxicity in several neurodegenerative disorders, including Huntington's disease. Recently, the eukaryotic chaperonin TRiC hetero-oligomeric complex has been shown to play an important r...

詳細記述

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書誌詳細
主要な著者: Kim, Sangjune, Park, Do-Young, Lee, Dohyun, Kim, Wanil, Jeong, Young-Hun, Lee, Juhyun, Chung, Sung-Kee, Ha, Hyunjung, Choi, Bo-Hwa, Kim, Kyong-Tai
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911496/
https://ncbi.nlm.nih.gov/pubmed/24298020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00756-13
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