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Vaccinated C57BL/6 Mice Develop Protective and Memory T Cell Responses to Coccidioides posadasii Infection in the Absence of Interleukin-10

High concentrations of lung tissue-associated interleukin-10 (IL-10), an anti-inflammatory and immunosuppressive cytokine, correlate with susceptibility of mice to Coccidioides spp. infection. In this study, we found that macrophages, dendritic cells, neutrophils, and both CD8(+) and CD4(+) T cells...

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Bibliographic Details
Main Authors: Hung, Chiung-Yu, Castro-Lopez, Natalia, Cole, Garry T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911407/
https://ncbi.nlm.nih.gov/pubmed/24478103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01148-13
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