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LSD1 Regulates Pluripotency of Embryonic Stem/Carcinoma Cells through Histone Deacetylase 1-Mediated Deacetylation of Histone H4 at Lysine 16

LSD1 is essential for the maintenance of pluripotency of embryonic stem (ES) or embryonic carcinoma/teratocarcinoma (EC) cells. We have previously developed novel LSD1 inhibitors that selectively inhibit ES/EC cells. However, the critical targets of LSD1 remain unclear. Here, we found that LSD1 inte...

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Bibliografski detalji
Glavni autori: Yin, Feng, Lan, Rongfeng, Zhang, Xiaoming, Zhu, Linyu, Chen, Fangfang, Xu, Zhengshuang, Liu, Yuqing, Ye, Tao, Sun, Hong, Lu, Fei, Zhang, Hui
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911295/
https://ncbi.nlm.nih.gov/pubmed/24190971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00631-13
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