Temporal Production of the Signaling Lipid Phosphatidic Acid by Phospholipase D2 Determines the Output of Extracellular Signal-Regulated Kinase Signaling in Cancer Cells

The Ras-extracellular signal-regulated kinase (ERK) cascade is an important signaling module in cells. One regulator of the Ras-ERK cascade is phosphatidic acid (PA) generated by phospholipase D (PLD) and diacylglycerol kinase (DGK). Using a newly developed PA biosensor, PASS (phosphatidic acid bios...

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Autors principals: Zhang, Feng, Wang, Ziqing, Lu, Maryia, Yonekubo, Yoshiya, Liang, Xiao, Zhang, Yueqiang, Wu, Ping, Zhou, Yong, Grinstein, Sergio, Hancock, John F., Du, Guangwei
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911278/
https://ncbi.nlm.nih.gov/pubmed/24164897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00987-13
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