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Amplification and Purification of T4-Like Escherichia coli Phages for Phage Therapy: from Laboratory to Pilot Scale

We investigated the amplification and purification of phage preparations with respect to titer, contamination level, stability, and technical affordability. Using various production systems (wave bags, stirred-tank reactors, and Erlenmeyer flasks), we obtained peak titers of 10(9) to 10(10) PFU/ml f...

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Main Authors: Bourdin, Gilles, Schmitt, Bertrand, Marvin Guy, Laure, Germond, Jacques-Edouard, Zuber, Sophie, Michot, Lise, Reuteler, Gloria, Brüssow, Harald
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911048/
https://ncbi.nlm.nih.gov/pubmed/24362424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.03357-13
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