The Natural Diyne-Furan Fatty Acid EV-086 Is an Inhibitor of Fungal Delta-9 Fatty Acid Desaturation with Efficacy in a Model of Skin Dermatophytosis

Human fungal infections represent a therapeutic challenge. Although effective strategies for treatment are available, resistance is spreading, and many therapies have unacceptable side effects. A clear need for novel antifungal targets and molecules is thus emerging. Here, we present the identificat...

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Autors principals: Knechtle, Philipp, Diefenbacher, Melanie, Greve, Katrine B. V., Brianza, Federico, Folly, Christophe, Heider, Harald, Lone, Museer A., Long, Lisa, Meyer, Jean-Philippe, Roussel, Patrick, Ghannoum, Mahmoud A., Schneiter, Roger, Sorensen, Alexandra S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910786/
https://ncbi.nlm.nih.gov/pubmed/24189258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01443-13
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