Novel Chimeric Lysin with High-Level Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus In Vitro and In Vivo

The treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) is a challenge worldwide. In our search for novel antimicrobial agents against MRSA, we constructed a chimeric lysin (named as ClyH) by fusing the catalytic domain of Ply187 (Pc) with the non-SH3b-like cell wall...

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Bibliographic Details
Main Authors: Yang, Hang, Zhang, Yun, Yu, Junping, Huang, Yanling, Zhang, Xian-En, Wei, Hongping
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Susceptibility
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910767/
https://ncbi.nlm.nih.gov/pubmed/24189265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01793-13
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