Maternal Administration of Solithromycin, a New, Potent, Broad-Spectrum Fluoroketolide Antibiotic, Achieves Fetal and Intra-Amniotic Antimicrobial Protection in a Pregnant Sheep Model

Solithromycin (CEM-101) is a new antibiotic that is highly potent against Ureaplasma and Mycoplasma spp. and active against many other antibiotic-resistant organisms. We have explored the maternal-amniotic-fetal pharmacokinetics of CEM-101 in a pregnant sheep model to assess its potential for treati...

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Detalhes bibliográficos
Main Authors: Keelan, Jeffrey A., Kemp, Matthew W., Payne, Matthew S., Johnson, David, Stock, Sarah J., Saito, Masatoshi, Fernandes, Prabhavathi, Newnham, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910757/
https://ncbi.nlm.nih.gov/pubmed/24189250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01743-13
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