RIG-I–like receptor LGP2 protects tumor cells from ionizing radiation

An siRNA screen targeting 89 IFN stimulated genes in 14 different cancer cell lines pointed to the RIG-I (retinoic acid inducible gene I)–like receptor Laboratory of Genetics and Physiology 2 (LGP2) as playing a key role in conferring tumor cell survival following cytotoxic stress induced by ionizin...

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Detalhes bibliográficos
Main Authors: Widau, Ryan C., Parekh, Akash D., Ranck, Mark C., Golden, Daniel W., Kumar, Kiran A., Sood, Ravi F., Pitroda, Sean P., Liao, Zhengkai, Huang, Xiaona, Darga, Thomas E., Xu, David, Huang, Lei, Andrade, Jorge, Roizman, Bernard, Weichselbaum, Ralph R., Khodarev, Nikolai N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910628/
https://ncbi.nlm.nih.gov/pubmed/24434553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323253111
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