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Coordinated Endothelial Nitric Oxide Synthase activation by translocation and phosphorylation determines flow-induced NO production in resistance vessels

BACKGROUND/AIMS: Endothelial nitric oxide synthase (eNOS) is associated with caveolin-1 (Cav-1) in plasma membrane. We tested the hypothesis that eNOS activation by shear stress in resistance vessels depends on synchronized phosphorylation, dissociation from Cav-1 and translocation of the membrane-b...

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Detalhes bibliográficos
Main Authors: Figueroa, Xavier F., González, Daniel R., Puebla, Mariela, Acevedo, Juan P., Rojas-Libano, Daniel, Durán, Walter N., Boric, Mauricio P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910107/
https://ncbi.nlm.nih.gov/pubmed/24217770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000355301
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