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Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

Cholinergic pathways serve important functions in learning and memory processes, and deficits in cholinergic transmission occur in Alzheimer disease (AD). A subset of muscarinic cholinergic receptors are linked to G-proteins that activate phospholipase C, resulting in the liberation of inositol tris...

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Bibliografiske detaljer
Main Authors: Kelly, J F, Furukawa, K, Barger, S W, Rengen, M R, Mark, R J, Blanc, E M, Roth, G S, Mattson, M P
Format: Artigo
Sprog:Inglês
Udgivet: 1996
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC39099/
https://ncbi.nlm.nih.gov/pubmed/8692890
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