Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

Cholinergic pathways serve important functions in learning and memory processes, and deficits in cholinergic transmission occur in Alzheimer disease (AD). A subset of muscarinic cholinergic receptors are linked to G-proteins that activate phospholipase C, resulting in the liberation of inositol tris...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kelly, J F, Furukawa, K, Barger, S W, Rengen, M R, Mark, R J, Blanc, E M, Roth, G S, Mattson, M P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39099/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8692890/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.13.6753
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