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A steroid receptor-microRNA switch that regulates lifespan in response to signals from the gonad
While the gonad primarily functions in procreation, it also affects animal lifespan. Here we show that removal of the C. elegans germline triggers a switch in the regulatory state of the organism to promote longevity, co-opting components involved in larval developmental timing circuits. These inclu...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3909774/ https://ncbi.nlm.nih.gov/pubmed/23239738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1228967 |
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